Personally, I tend to get most of my basic lab supplies from within the UK for the sake of convenience and speed, but for more specialized items, I've definitely looked at international options. Turnaround times can vary massively depending on the supplier and what you're ordering. For some of the more obscure reagents, it's just unavoidable. I've found that gentaur often has competitive prices, especially if you're buying in bulk. Also, make sure you factor in shipping and import costs when comparing prices. It's also useful to check their documentation and see if they provide detailed information about
lysosome structure of the materials they sell. This can save time trying to determine whether they meet your quality control specifications.